Division of Forensic Sciences

Toxicology Section

The Division of Forensic Sciences (DOFS) Toxicology Section provides state and local law enforcement officials and medical examiners with vital information about human biological samples and specifically whether drugs, alcohol or poisons may have played a role in the commission of a crime or a death.

By analyzing blood, urine, stomach contents and tissues, DOFS toxicologists are able to establish whether traces of alcohol, drugs or poisons are present, and if so, in what quantity.

Hitachi 911 Analyzer
The Hitachi 911 analyzer is used to screen biological specimens for common drugs of abuse.

The Toxicology Section provides two primary services:

  • Alcohol and drug testing for impaired drivers.
  • Medical examiner death investigation testing.

The testing process is time consuming and begins with the receipt of a biological sample. The sample is then assigned a unique DOFS case number and bar coded prior to being assigned to a toxicologist for analysis. After undergoing an initial drug screening,  positive samples are extracted by a toxicologist and analyzed using state of the art chemical instrumentation. The test data are then interpreted by the toxicologist and the results of their analysis and conclusions are entered into the DOFS Laboratory Information Management System (LIMS). The results and conclusions of the toxicologist are then checked independently by another toxicologist who has to concur with their findings. Once this step is complete an official report is generated and released to the officer or agency that submitted the sample.


Bio Specimens Extraction
Bio Specimens Extraction
Bio Specimens Analyzed
Drugs are isolated from biological specimens through solid phase extraction. The extraction is then analyzed by a gas chromatograph-mass spectrometer to determine the type of drug.

Analysis to Detect Presence of Alcohol and/or Drugs
A toxicologist prepares blood specimens for analysis by a headspace gas chromatograph for the presence of alcohol and/or drugs.

Impaired Drivers

On average, the unit, made up of scientists and technicians, spends about 60 percent of its time working on cases involving drivers suspected of driving under the influence of alcohol or drugs (DUI). In fact, DOFS toxicologists processed about 10,000 traffic-related cases in 2000. While both blood and urine samples are taken at the time of an arrest, the sample analyzed depends on the analysis requested and the particularities of a given case. With the help of instruments such as a headspace gas chromatograph (GC) up to 35 samples may be tested at one time to determine the presence and the exact quantity of alcohol in a sample. Likewise, by use of a gas chromatograph-mass spectrometer (GC-MS) minute amounts of drugs may be detected and the exact quantity present determined as well. The results of these tests will play a role in determining if charges will be brought against a driver for operating a motor vehicle under the influence of alcohol and/or drugs. By far and away the most common drugs found, after alcohol, are cocaine and marijuana. However, date rape drugs like gamma hydroxy butyrate (GHB) are being seen more and more often.


Medical Examiner Death Investigations

Similar to tests run in DUI cases, blood, urine and other bodily materials also supply toxicologists with clues into the cause of a death. Whether a victim was shot, stabbed or died from blunt force trauma, DOFS toxicologists are routinely called upon to determine if drugs or poisons may have played a role in the death. Blood, tissue and stomach contents can all provide valuable information when analyzed with a GC-MS as to the type and quantities of drugs involved in a death. The Toxicology section tested about 12,000 samples for drugs in 2000.

A toxicologist prepares to test samples submitted by the Medical Examiner's Office
A toxicologist prepares to test samples submitted by the Medical Examiner's Office

Poisons

Despite what television portrays, homicidal poisonings are rare. Carbon monoxide is the most frequently discovered poison. Often the victims are exposed to the deadly gas from a fire, automobile exhaust or from faulty heating system. Other poisons routinely checked for are the "classic" poisons like cyanide, arsenic and strychnine. These substances can sometimes be found in victims of homicide, but more commonly encountered in suicides and accidental poisonings. DOFS toxicologists are also capable of identifying a variety of pesticides, poisonous plants and rare or unusual toxins. These poisons typically require an experienced and well trained-eye to identify. The Toxicology section has scientists who specialize in this type testing to aid in the analysis of undetermined or suspicious death cases.


Analysis to detect Metals

Biological samples are prepared for Inductively Conductive Plasma/Mass Spectrometer (ICP-MS) analysis to detect heavy metals such as arsenic.


Detecting the Presence of an Inhalant
To test for inhalants, a volatile gas standard is collected that will be used to compare to a biological specimen for detecting the presence of an inhalant.

Inhalants

The Toxicology section also is responsible for identifying inhalant abuse, such as seen by the inhalation of solvents, glues, freon and nitrous oxides. The section receives between two to five cases involving inhalants each month, with the majority of the victims under the age of 30 years old. In fact, a recent study revealed one in five eighth grade students have sniffed glue or "huffed" household product. Huffing is when an aerosol or solvent is placed in an almost closed area, like a soda can or bag and the fumes are inhaled. Among products commonly abused are computer and VCR cleaning solutions, cigarette lighter fluid, barbecue fuels and correction fluid or markers. Both sniffing glue and huffing kill brain cells and can lead to death. To determine what chemicals are present in cases where inhalants are believed to be involved, a DOFS toxicologist uses chemical instrumentation such as GC and GC-MS to analyze the residual air left in a lung or the chemicals that may be found in the blood of a huffing victim.

With demands on the Toxicology section growing each day, the unit has recently grown through the addition of 30 additional scientists to the statewide program. The employees will be assigned to one of six toxicology labs in the state. The other labs are located in Augusta, Columbus, Macon, Moultrie, Savannah and Summerville.

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